Ethinyl Estradiol Dose, Progestin Type Affect the Pill's Stroke Risk

However, risk of thrombotic stroke and myocardial infarction is generally low for oral contraceptives

WEDNESDAY, June 13 (HealthDay News) -- The risk of thrombotic stroke and myocardial infarction is increased for women who take oral contraceptives that include ethinyl estradiol, with the relative risk varying according to the dose of ethinyl estradiol and the progestin type, according to a study published in the June 14 issue of the New England Journal of Medicine.

Øjvind Lidegaard, Dr.Med.Sci., from the University of Copenhagen in Denmark, and colleagues utilized data from national registries to assess the risk of thrombotic stroke and myocardial infarction in 1,626,158 nonpregnant women (aged 15 to 49 years) with no history of cardiovascular disease or cancer.

Over the 15-year cohort study, the researchers found that there were 3,311 thrombotic strokes (21.4 per 100,000 person-years) and 1,725 myocardial infarctions (10.1 per 100,000 person-years). Compared with nonuse, current use of oral contraceptives that included 30 to 40 µg ethinyl estradiol correlated with an increased relative risk for thrombotic stroke and myocardial infarction which varied according to progestin type (1.5 to 2.2 and 1.3 to 2.3, respectively. Compared with nonuse, the relative risk with use of oral contraceptives that included 20 µg ethinyl estradiol was 0.9 to 1.7 and 0.0 to 1.6, respectively, for thrombotic stroke and myocardial infarction. The corresponding relative risks were 3.2 and 0.0 for transdermal patches and 2.5 and 2.1 for the vaginal ring.

"The absolute risks of thrombotic stroke and myocardial infarction associated with the use of hormonal contraception were low," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry; one author provided expert testimony in a legal case pertaining to the study.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events