Multiple Tumor Zones Should Be Sampled in Breast Cancer

Considerable heterogeneity found within tumor, lymph node metastases of any particular patient

MONDAY, June 18 (HealthDay News) -- For any given patient with breast cancer, the expression of microRNAs (miRNAs), which has been linked to tumor development and progression, varies greatly within the same tumor and lymph node metastases, according to a study published online June 18 in The Journal of Molecular Diagnostics.

Mithu Raychaudhuri, Ph.D., from the Technische Universität München in Munich, Germany, and colleagues compared the expression of four miRNAs (miR-10b, miR-210, miR-31, and miR-335) and control genes in peripheral, intermediate, and central tumor zones, as well as in lymph node metastases (if present), from 16 patients with large primary invasive breast cancer (132 samples total).

The researchers found that for any particular patient there was considerable heterogeneity both within the tumor and lymph node metastases for all four miRNAs (coefficient of variation [CV], 33 to 40 percent), with similar heterogeneity within and between tumor zones. The variation was even greater among different patients, both for the primary tumor (CV, 80 percent) and lymph node metastases (CV, 103 percent).

"An important strength of this study is the systematic and predefined prospective sampling of tumors in eight to 10 different areas, whereas previous studies have commonly only analyzed different areas of one tumor section, or core biopsies of the same tumor," a coauthor said in a statement. "Reliable assessment of breast cancer miRNA profiles should include sampling of the primary tumor in several locations or sampling several tumor-involved lymph nodes when deriving miRNA expression profiles from metastases."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events