ENDO: Serum Phthalate Levels Higher in Obese Children

Dose-dependent increased obesity risk seen with increase in serum di(2-ethylhexyl) phthalate

MONDAY, June 25 (HealthDay News) -- Serum levels of di(2-ethylhexyl) phthalate (DEHP) are increased in obese versus nonobese children, according to a study presented at the annual meeting of The Endocrine Society, held from June 23 to 26 in Houston.

Shin Hye Kim and Mi Jung Park, M.D., Ph.D., from the Inje University College of Medicine in Seoul, Korea, and colleagues examined the association between DEHP level and obesity in 204 children (105 obese cases and 99 controls; aged 6 to 13 years). Measurements of fasting glucose, insulin, aspartate aminotransferase, alanine aminotransferase (ALT), uric acid, and lipid profiles were taken. Gas chromatography/mass spectrometry was used to analyze serum DEHP levels.

The researchers found that, compared with controls, geometric mean serum DEHP levels were significantly higher in obese children. Serum DEHP level showed a significant positive correlation with body mass index, serum ALT, uric acid, and body fat mass, when controlling for potential covariates. There was no significant correlation seen between serum DEHP level and high-density lipoprotein cholesterol, triglycerides, fasting blood sugar, and fasting insulin. After adjustment for age, gender, physical activity, household income, and daily calorie intake, there was a dose-dependent increase in the risk of obesity with increasing serum DEHP quartiles (odds ratios: quartile 2, 1.25; quartile 3, 3.63; quartile 4, 5.04).

"Although this study cannot prove causality between childhood obesity and phthalate exposure, it alerts the public to recognize the possible harm and make efforts to reduce this exposure, especially in children," Park said in a statement.

More Information

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events