Early Vaccinations Not Linked to Celiac Disease in Sweden

Changes in vaccinations don't account for epidemic; BCG vaccine linked to reduced risk

MONDAY, June 25 (HealthDay News) -- Early vaccinations do not seem to influence the risk of celiac disease (CD) among infants, nor do changes in the vaccination program explain the CD epidemic, according to a Swedish study published online June 25 in Pediatrics.

To investigate whether changes in the national Swedish vaccination program coincided with changes in the incidence of CD in infants, Anna Myléus, Ph.D., M.D., from Umeå University in Sweden, and colleagues analyzed data from the National Swedish Childhood Celiac Disease Register and performed a population-based incident case-referent study of infants. Questionnaires and child health clinic records were used to obtain exposure information. The responses to the following vaccines were examined: diphtheria/tetanus, pertussis (acellular), polio (inactivated), Haemophilus influenza type b (conjugated), measles/ mumps/rubella, and live attenuated bacillus Calmette-Guérin (BCG; given to children with increased tuberculosis risk).

The researchers found that the introduction of the pertussis vaccine coincided in time with decreasing CD incidence rates, but there was no association seen between CD and vaccination against pertussis (odds ratio, 0.91; 95 percent confidence interval, 0.60 to 1.4), Haemophilus influenza type b, or measles/mumps/rubella. BCG correlated with decreased risk for CD (adjusted odds ratio, 0.54), but discontinuation of general BCG vaccination had no impact on the cumulative incidence of CD at age 15 years.

"The Swedish epidemic of CD is not fully understood, and changes in the vaccination program or coverage do not contribute to the explanation," the authors write. "We found no epidemiologic evidence that the immunologic response to vaccinations increases CD risk."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events