View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, June 25 (HealthDay News) -- Ozone exposure in healthy young adults causes an increase in vascular markers of inflammation, changes in fibrinolytic markers that could potentially impair fibrinolysis, and changes in autonomic control of heart rate, according to a study published online June 25 in Circulation.
Robert B. Devlin, Ph.D., from the U.S. Environmental Protection Agency in Research Triangle Park, N.C., and colleagues exposed 23 young healthy individuals to clean air and to 0.3-ppm ozone for two hours during intermittent exercising. Before exposure, immediately after exposure, and the next morning, blood was obtained. Participants used a continuous Holter monitor immediately after exposure for a 24-hour period. Additionally, lung function was performed immediately before and immediately after exposure, and bronchoalveolar lavage was performed 24 hours after exposure.
The researchers found a 98.9 percent increase in interleukin-8, a 21.4 percent decrease in plasminogen activator inhibitor-1, a 51.3 percent decrease in the high-frequency component of heart rate variability, and a 1.2 percent increase in QT duration, immediately after ozone exposure. Twenty-four hours after exposure, changes in interleukin-1B and plasminogen activator inhibitor-1 were apparent. Participants also had ozone-induced drops in lung function and an increase in pulmonary inflammation.
"This study provides a plausible explanation for the link between acute ozone exposure and death," Devlin said in a statement.
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top