Ozone Exposure Causes Negative Cardiovascular Changes

Physiological changes in healthy volunteers from ozone exposure mirror cardiovascular ailments

MONDAY, June 25 (HealthDay News) -- Ozone exposure in healthy young adults causes an increase in vascular markers of inflammation, changes in fibrinolytic markers that could potentially impair fibrinolysis, and changes in autonomic control of heart rate, according to a study published online June 25 in Circulation.

Robert B. Devlin, Ph.D., from the U.S. Environmental Protection Agency in Research Triangle Park, N.C., and colleagues exposed 23 young healthy individuals to clean air and to 0.3-ppm ozone for two hours during intermittent exercising. Before exposure, immediately after exposure, and the next morning, blood was obtained. Participants used a continuous Holter monitor immediately after exposure for a 24-hour period. Additionally, lung function was performed immediately before and immediately after exposure, and bronchoalveolar lavage was performed 24 hours after exposure.

The researchers found a 98.9 percent increase in interleukin-8, a 21.4 percent decrease in plasminogen activator inhibitor-1, a 51.3 percent decrease in the high-frequency component of heart rate variability, and a 1.2 percent increase in QT duration, immediately after ozone exposure. Twenty-four hours after exposure, changes in interleukin-1B and plasminogen activator inhibitor-1 were apparent. Participants also had ozone-induced drops in lung function and an increase in pulmonary inflammation.

"This study provides a plausible explanation for the link between acute ozone exposure and death," Devlin said in a statement.

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

What internal motivators drive RNs to pursue a BSN?
Nursing2014 , October 2014
Free access will expire on November 24, 2014.


Breast Cancer Risk Assessment in Primary Care
MCN, The American Journal of Maternal/Child Nursing, September/October 2014
Free access will expire on November 10, 2014.


Nurses spurring innovation
Nursing Management, October 2014
Free access will expire on November 10, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events