Apolipoproteins Are Biomarkers for Diabetic Retinopathy

Serum apoliproteins linked to markers of systemic, retinal microvascular dysfunction in diabetes

FRIDAY, June 29 (HealthDay News) -- In patients with diabetes, with or without diabetic retinopathy, serum apolipoproteins (apos) are associated with markers of systemic and retinal microvascular dysfunction, according to a study published in the July issue of Diabetes.

Muhammad Bayu Sasongko, M.D., from the University of Melbourne in Australia, and colleagues investigated whether apoAI and apoB levels correlated with measures of systemic and retinal microvascular function in 224 patients with diabetes (85 type 1 and 139 type 2). Serum lipids and lipoproteins from fasting blood; skin responses to sodium nitroprusside (endothelium independent) and acetylcholine (ACh) (endothelium dependent) iontophoresis; flicker-light-induced retinal vasodilatation; and retinal vascular tortuosity were assessed.

The researchers found that every standard deviation (SD) increase in apoAI level correlated significantly with ACh-induced skin perfusion (mean change, 1.27 percent) and flicker-light retinal arteriolar vasodilatation (0.33 percent), while there was an inverse correlation with arteriolar tortuosity (−2.83 × 10−5), after adjustment for age and sex. These associations persisted in multivariable models. For apoB, each SD increase correlated significantly with arteriolar tortuosity only (1.75 × 10−5). Serum apoAI was inversely related to retinal vessel tortuosity and correlated positively with increased vasomotor responsiveness to ACh and flickering light.

"Our findings may elucidate the role of apos in diabetic retinopathy and support previous evidence that serum apos are stronger biomarkers for diabetic retinopathy, and possibly other diabetic microvascular complications, than traditional lipids," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events