View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, July 3 (HealthDay News) -- The rheumatoid arthritis drug leflunomide is not a major cause of birth defects in women who inadvertently become pregnant while taking the drug, although pregnancy should be avoided, according to a study in the July issue of Arthritis & Rheumatism.
Building on a previous study showing that leflunomide was not linked to adverse pregnancy outcomes, Matteo Cassina, M.D., from the University of Padua in Italy, and colleagues examined birth outcomes in 45 pregnant women exposed to leflunomide: 16 who were exposed during the first trimester and 29 who were exposed prior to conception.
The researchers found that livebirths were experienced by all 16 women exposed to leflunomide during the first trimester and by 27 women (93 percent) exposed before conception. There were two infants with major malformations, both from mothers exposed during pregnancy. At least some of the defects observed could be attributed to other causes.
"These data provide additional reassurance that leflunomide is not a major human teratogen in women who inadvertently become pregnant while taking leflunomide and who undergo the washout procedure," Cassina and colleagues conclude. "However, until more conclusive data become available, women receiving such therapy should still be advised to use contraceptive methods and avoid pregnancy."
The study was supported by Sanofi-Aventis; one author disclosed financial ties to pharmaceutical companies, including Sanofi-Aventis.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top