Factors ID'd for Outcome of Percutaneous Nephrolithotomy

Increasing stone size, upper pole stones associated with lower rates of stone clearance

TUESDAY, July 3 (HealthDay News) -- Single-tract percutaneous nephrolithotomy (sPCNL) is effective for clearing renal stones, with stone size, location, and prior shockwave lithotripsy (SWL) identified as independent predictors of stone clearance, according to a study published in the July issue of Urology.

Khaled Shahrour, M.D., from the University of Toledo Medical Center in Ohio, and colleagues conducted a retrospective review of 351 cases of sPCNL performed by one of two endourologists at a single institution between January 2000 and March 2010. Analyses included preoperative patient and stone factors.

The researchers found that the stone-free rate (SFR) was 76 percent after either an initial procedure or a second-look nephroscopy. Lower SFR correlated with rising preoperative creatinine, hypertension, increasing stone diameter, complete staghorn stone, presence of stones in the upper pole, and absence of prior SWL, in univariate analysis. In multivariate analysis, stone size, presence of stones in the upper pole, and prior SWL for the active burden remained independent predictors of SFR.

"The purpose of the study is to evaluate the preoperative factors that affect outcome of sPCNL, to aid urologists and patients in making the most appropriate decisions concerning the type of stone treatment," the authors write. "Further development of a predictive nomogram of stone clearance and complications is currently being performed"

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