GI Cancer Resection OK With Mild Cirrhotic Liver Dysfunction

For patients with cirrhosis, moderate-to-severe liver dysfunction linked to post-op mortality

TUESDAY, July 10 (HealthDay News) -- For patients with cirrhosis, resection of gastrointestinal (GI) malignancies correlates with poor early postoperative outcomes, with severity of liver disease being the primary determinant of postoperative mortality, according to a study published in the July issue of Cancer.

To examine early postoperative and transitional outcomes in cirrhotic patients undergoing GI cancer surgery, Avo Artinyan, M.D., from the Michael E. DeBakey VA Medical Center in Houston, and colleagues analyzed data from the National Inpatient Sample Database (2005 to 2008) and identified 106,729 patients who underwent resection for GI malignancy, of whom 1,479 (1.4 percent) were diagnosed with cirrhosis.

The researchers found that patients with cirrhosis had a significantly increased risk of in-hospital mortality (8.9 versus 2.8 percent), longer length of stay (11.5 ± 0.26 versus 10.0 ± 0.03 days), and higher rate of discharge to long-term care facilities (19.0 versus 15.7 percent). Patients with moderate-to-severe liver dysfunction had the highest mortality (21.5 versus 6.5 percent). Cirrhosis was an independent predictor of in-hospital mortality and non-home discharge (odds ratios [ORs], 3.0 and 1.7, respectively), in multivariate analysis. Moderate-to-severe liver dysfunction was the only independent predictor of in-hospital mortality for patients with cirrhosis (OR, 4.03).

"Resection of GI malignancy in cirrhotics is associated with poor early postoperative and transitional outcomes, with severity of liver disease being the primary determinant of postoperative mortality," the authors write. "These data suggest that GI cancer operations can be performed safely in well-selected cirrhotic patients with mild liver dysfunction."

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events