Unsuccessful Fertility Drug Use Lowers Breast Cancer Risk

Protective association disappears among women who successfully conceive on fertility drugs

MONDAY, July 9 (HealthDay News) -- Women with unsuccessful use of fertility drugs are at a significantly reduced risk of young-onset breast cancer, according to a study published online July 6 in the Journal of the National Cancer Institute.

To examine the association between fertility drug use and young-onset breast cancer, Chunyuan Fei, Ph.D., from the National Institute of Environmental Health Sciences in Research Triangle Park, N.C., and colleagues conducted a sister-matched case-control study that included 1,422 cases who were younger than age 50 years at diagnosis with breast cancer, enrolled within four years of diagnosis, and 1,669 breast cancer-free control sisters.

The researchers found that 288 participants reported using ovulation-stimulating drugs (193 clomiphene citrate only; 29 follicle-stimulating hormone only; 66 both). Compared with nonusers, women who had used fertility drugs had a nonsignificantly decreased risk of breast cancer (odds ratio [OR], 0.82; 95 percent confidence interval [CI], 0.63 to 1.08). Compared with nonusers, women who had used fertility drugs but had not conceived a 10+ week pregnancy had a significantly decreased risk of breast cancer (OR, 0.62). Compared with unsuccessfully treated women, women who had conceived using fertility drugs had a significantly increased risk of breast cancer (OR, 1.82); their risk was similar to women who had not used fertility drugs (OR, 1.13; 95 percent CI, 0.78 to 1.64).

"In this sister-based case-control study, a history of unsuccessful use of ovulation-stimulating fertility drugs was associated with a statistically significantly reduced risk of young-onset breast cancer, but the occurrence of a stimulated 10+ week pregnancy appeared to offset the protective association," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Dogs as Pets, Visitors, Therapists and Assistants
Home Healthcare Nurse, November/December 2014
Free access will expire on January 5, 2015.


Tracheostomy Care
Nursing2014 Critical Care, November 2014
Free access will expire on December 22, 2014.


Effective management of ARDS
The Nurse Practitioner, 13December 2014
Free access will expire on December 22, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events