Trackable Blood Cells Feasible for MRI Monitoring

Blood cells labeled with superparamagnetic iron particles detectable by magnetic resonance imaging

WEDNESDAY, July 11 (HealthDay News) -- Blood cells labeled with superparamagnetic particles of iron oxide (SPIO) are safe and can be tracked by magnetic resonance imaging (MRI), which may allow better monitoring of cell-based therapies, according to a study published online July 10 in Circulation: Cardiovascular Imaging.

Jennifer M.J. Richards, M.B., Ch.B., from the University of Edinburgh in the United Kingdom, and colleagues labeled peripheral blood mononuclear cells with SPIO and tested their ability to be detected by MRI after intramuscular or intravenous injection into humans.

The researchers found that the SPIO-labeled cells could be detected for at least seven days following intramuscular injection. Injecting as many as one billion labeled cells was safe, with cells accumulating in the reticulo-endothelial system and detectable in clinical MRI. When injected intravenously into a healthy volunteer, the SPIO-labeled cells were able to migrate to a site of inflammation, which could be detected both by MRI and through skin biopsies confirming the presence of iron.

"SPIO-labeling for magnetic resonance cell tracking is a safe and feasible technique that has major potential for a range of cardiovascular applications, including monitoring of cell therapies and tracking of inflammatory cells," Richards and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events