Factors Influencing Hepatitis C RNA Levels in Drug Users ID'd

Factors include age, gender, racial ancestry, HIV-1 infection, HCV genotype, and IL28B genotype

MONDAY, July 16 (HealthDay News) -- Levels of hepatitis C virus (HCV) RNA in injection drug users are independently associated with various demographic, viral, and host genetic factors, including being older, male, African-American, and co-infected with HIV, according to a study published in the July issue of Hepatology.

Lorenzo Uccellini, Ph.D., from the National Institutes of Health in Bethesda, Md., and colleagues analyzed factors influencing HCV RNA levels in an ethnically and racially diverse group of 1,701 individuals with HCV viremia (median age, 46 years) who were injection drug users (median duration of drug use, 26 years). Of these, 13.9 percent were co-infected with HIV.

The researchers found that the median level of HCV RNA was 6.45 log10 copies/mL. Higher RNA levels were found in those who were older, male, African-American, infected with hepatitis B virus or HIV, carrying the IL28B rs12979860-CC genotype, and infected with HCV genotype 1 compared with genotype 3 or 4, in unadjusted analyses. Age, gender, racial ancestry, HIV-1 co-infection, HCV genotype, and IL28B rs12979860 genotype were independently associated with HCV RNA levels, after adjustment for various factors.

"In conclusion, level of HCV viremia, an important predictor of response to HCV treatment, is itself influenced by a wide range of demographic, viral, and host genetic factors," Uccellini and colleagues write. "A better understanding of the determinants of HCV viremia might lead to improved treatment of patients with chronic hepatitis C."

One author disclosed financial ties to the pharmaceutical and biotechnology industries.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events