Free Light Chains Identified in Chronic Rhinosinusitis

Increased concentration of free light chains most prominent in those with nasal polyps

MONDAY, July 16 (HealthDay News) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Tom Groot Kormelink, of Utrecht University in the Netherlands, and associates analyzed nasal tissue, nasal secretion, and serum of patients with CRSwNP and CRS without nasal polyps (CRSsNP) to determine the presence of FLCs. The effect of different treatments on the expression of FLCs was examined.

The researchers found that patients with CRS had increased FLC concentrations in nasal secretion and mucosal tissue homogenates, and the increase was most prominent in patients with CRSwNP. The increase in FLC in nasal polyp tissue was confirmed by immunohistochemistry. Treatment with methylprednisolone or anti-interleukin-5 (IL-5) resulted in the reduction in systemic or local FLC concentrations, respectively, in patients with CRSwNP.

"The presence of FLC in CRSwNP and CRSsNP suggests a possible role in mediating the local immune reaction in the paranasal cavities," the authors write. "Furthermore, the decrease in local FLCs after treatment with anti-IL-5 presumes that IL-5 creates an environment that favors FLC production."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events