View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, July 27 (HealthDay News) -- Mephedrone, a synthetic stimulant known as "bath salts," stimulates reward centers in the brain in a similar manner to cocaine, indicating a high potential for abuse, according to a study published in the Sept. 1 issue of Behavioural Brain Research.
J. Elliott Robinson, from the University of North Carolina at Chapel Hill, and colleagues examined the ability of mephedrone and cocaine to alter the response of mice to intracranial self-stimulation of the medial forebrain bundle, which is involved in reward perception.
The researchers found that, beginning 15 minutes after mephedrone administration, there was a dose-dependent decrease in the half maximal responding (maximum effect, 72.3 percent of baseline), the brain stimulation reward threshold (maximum effect, 59.6 percent of baseline), and the maximum response rate (maximum effect, 67.0 percent of baseline). Similar results were observed immediately after administration of cocaine, with similar potencies, although there was no effect on maximum response rate.
"The effects of mephedrone on the brain's reward circuits are comparable to similar doses of cocaine," Robinson said in a statement. "As expected our research shows that mephedrone likely has significant abuse liability."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top