View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Aug. 6 (HealthDay News) -- Complex inheritance is usual in vasovagal syncope, with major autosomal dominance less common, according to a study published in the Aug. 7 issue of Neurology.
To examine the role of genetic factors in vasovagal syncope, Karl Martin Klein, M.D., Ph.D., of the Epilepsy Research Centre at the University of Melbourne in Australia, and colleagues conducted a study involving 51 sets of same-sex twin pairs, between the ages of 9 and 69 years, where at least one twin had a history of syncope.
The researchers found that, for any syncope, there was a trend toward higher case-wise concordance in monozygous (MZ) than dizygous (DZ) twins (P = 0.06). The effect on concordance was significantly different for MZ and DZ twins for fainting at least twice unrelated to external factors (P = 0.018) and for syncope associated with typical vasovagal triggers (P < 0.001). There were sparse or no family members affected in 12 of 19 concordant MZ pairs, while multiple close relatives were affected in the other seven pairs.
"The twin analysis provides strong evidence for the relevance of genetic factors in vasovagal syncope," the authors write. "Analysis of the families suggests that complex inheritance (multiple genes ± environmental factors) is usual, with rarer families possibly segregating a major autosomal dominant gene."
One author disclosed financial ties to the pharmaceutical industry and may accrue revenue from a pending patent.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top