Drug Helps Control Glucose in Congenital Hyperinsulinism

Glucagon-like peptide-1 receptor antagonist controls blood glucose and insulin levels

TUESDAY, Aug. 7 (HealthDay News) -- An experimental drug may be able to control blood glucose levels in patients with a form of congenital hyperinsulinism, according to a study published online Aug. 1 in Diabetes.

Andrew C. Calabria, M.D., from the Children's Hospital of Philadelphia, and colleagues treated nine patients with congenital hyperinsulinism due to inactivating mutations in the potassium adenosine triphosphate (ATP) channel (KATPHI) with exendin-(9-39) (a glucagon-like peptide-1 receptor antagonist) or vehicle on two different days.

The researchers found that subjects treated with exendin-(9-39) had increased mean nadir blood glucose and glucose area under the curve during fasting. Exendin-(9-39) also lowered insulin-to-glucose ratios but had no effect on fasting glucagon and intact glucagon-like peptide-1. Insulin secretion from pancreatic islets from newborns with KATPHI was inhibited after treatment with exendin-(9-39).

"Our data show that exendin-(9-39) elevates fasting glucose in human subjects with KATPHI," Calabria and colleagues conclude. "Given the lack of available therapies, antagonism of the glucagon-like peptide-1 receptor represents a novel therapeutic target to control hypoglycemia in congenital hyperinsulinism and could have a beneficial impact on morbidity and improve long-term outcomes for this devastating disorder."

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events