View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Aug. 13 (HealthDay News) -- Moxifloxacin and levofloxacin use correlates with an increased risk of acute liver injury in older patients without a history of liver disease, according to a study published online Aug. 13 in CMAJ, the journal of the Canadian Medical Association.
J. Michael Paterson, of the Institute for Clinical Evaluative Sciences in Toronto, and colleagues conducted a population-based, nested, case-control study involving 144 patients aged 66 years or older with no history of liver disease who were admitted to the hospital for acute liver injury within 30 days of receiving a prescription for moxifloxacin, levofloxacin, ciprofloxacin, cefuroxime axetil, or clarithromycin. Ten age- and sex-matched controls who had received an antibiotic but were not admitted to hospital were selected for each case.
The researchers found that the majority of hospitalized patients (61.1 percent) died in the hospital. Compared with clarithromycin, use of moxifloxacin or levofloxacin correlated with an increase in the risk of acute liver injury (adjusted odds ratio, 2.20 and 1.85, respectively). No increased risk was seen for ciprofloxacin or cefuroxime axetil.
"Relative to the use of clarithromycin, the use of moxifloxacin and levofloxacin was associated with an increase (about two-fold) in the risk of admission to hospital for acute liver injury among the patients in our cohort," the authors write. "Although our results require confirmation in other settings, they suggest that both moxifloxacin and levofloxacin be considered for regulatory warnings regarding acute liver injury."
One author disclosed financial ties to the pharmaceutical industry.
Editorial (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top