L-Carnitine Does Not Reduce Cancer-Related Fatigue

No relief for patients with invasive malignancies given L-carnitine supplementation 2 g/day for four weeks

TUESDAY, Sept. 18 (HealthDay News) -- Patients with invasive malignancies who take L-carnitine supplements do not experience a reduction in fatigue, pain, or depression, according to research published online Sept. 17 in the Journal of Clinical Oncology.

To determine whether L-carnitine improves fatigue in cancer patients, Ricardo A. Cruciani, M.D., of the Beth Israel Medical Center in New York City, and colleagues conducted an Eastern Cooperative Oncology Group phase III, randomized, double-blind, placebo-controlled study involving 376 patients with invasive malignancies who received either 2 g/day of L-carnitine oral supplement or matching placebo for four weeks.

The researchers found that fatigue, as measured using the Brief Fatigue Inventory, improved in both treatment arms compared with baseline, but there was no significant between-group difference. In a subgroup analysis, L-carnitine supplementation also did not improve fatigue in those who were carnitine-deficient at baseline. Neither depression nor pain was improved, as measured using the Functional Assessment of Chronic Illness Therapy-Fatigue instrument. The improvement in both arms suggests a large placebo effect.

"This is the largest clinical trial to date studying the effect of L-carnitine supplementation on patients with invasive malignancy and fatigue," the authors write. "In this phase III, randomized, double-blind, placebo-controlled study, we observed that 1 g twice daily of oral L-carnitine supplementation for four weeks does not improve fatigue, depression, or pain in patients with cancer."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Meeting the Needs of Family Members of ICU Patients
Critical Care Nursing Quarterly, October/December 2014
Free access will expire on December 22, 2014.


Dealing with the specter of phantom limb pain
Nursing2014 , November 2014
Free access will expire on December 8, 2014.


The Power of Nursing Peer Review
JONA: Journal of Nursing Administration, November 2014
Free access will expire on December 8, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events