View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Oct. 1 (HealthDay News) -- Patients taking β-blockers for hypertension, which can disturb sleep, have improved sleep quality with melatonin treatment, according to a study published in the Oct. 1 issue of SLEEP.
Frank A.J.L. Scheer, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues randomly assigned 16 patients taking β-blockers for hypertension to placebo or 2.5 mg melatonin nightly for three weeks. Sleep was assessed in two four-day in-laboratory admissions before and after treatment.
As assessed by polysomnography, the researchers found that the melatonin group had significantly increased sleep time (36 minutes); significantly greater sleep efficiency (7.6 percent); significantly shorter sleep onset latency to Stage 2 (−14 minutes); and significantly more Stage 2 sleep (41 minutes). There were no significant differences in the duration of other sleep stages. On the night following discontinuation of melatonin, sleep onset latency remained significantly shorter (by 25 minutes).
"In hypertensive patients treated with β-blockers, three weeks of nightly melatonin supplementation significantly improved sleep quality, without apparent tolerance, and without rebound sleep disturbance during withdrawal of melatonin supplementation (in fact, a positive carry-over effect was demonstrated)," Scheer and colleagues conclude. "These findings may assist in developing countermeasures against sleep disturbances associated with β-blocker therapy."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top