View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Oct. 10 (HealthDay News) -- Fibulin-3 levels in plasma and lung fluids can discriminate patients with mesothelioma from others with asbestos exposure or those whose lung effusions are unrelated to mesothelioma, according to a study published in the Oct. 11 issue of the New England Journal of Medicine.
Harvey I. Pass, M.D., from the New York University Langone Medical Center in New York City, and colleagues examined whether fibulin-3 levels in plasma were a good biomarker for pleural mesothelioma in 92 patients with mesothelioma, 136 asbestos-exposed persons without cancer, 93 patients with effusions not due to mesothelioma, and 43 healthy controls. Fibulin-3 levels were also measured in effusions (from 74 patients with mesothelioma, 39 with benign effusions, and 54 with malignant effusions not related to mesothelioma) or in both plasma and effusions.
The researchers found that plasma fibulin-3 levels were significantly higher in patients with pleural mesothelioma than in asbestos-exposed persons without mesothelioma. In pleural effusions, fibulin-3 levels were significantly higher in patients with pleural mesothelioma than in patients with effusions not due to mesothelioma. Further validation showed fibulin-3 staining in 100 percent of 26 tumor samples. In comparing patients with and without mesothelioma, plasma fibulin-3 levels had a sensitivity of 96.7 percent and a specificity of 95.5 percent at a cut-off of 52.8 ng/mL fibulin-3. On blinded validation of a sample of plasma specimens from 96 asbestos-exposed patients and 48 patients with mesothelioma, the area under the curve was 0.87.
"The results of our study suggest that levels of fibulin-3 in plasma and effusions may aid in determining the diagnosis and prognosis of pleural mesothelioma," Pass and colleagues conclude.
Several authors disclosed financial conflicts of interest, including mesothelioma-related expert testimony, patents, and ties to the biotechnology and pharmaceutical industries.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top