Review Compares Effectiveness of Tocolytic Agents

Prostaglandin inhibitors and calcium channel blockers most effective for delaying delivery

WEDNESDAY, Oct. 10 (HealthDay News) -- The most effective tocolytic agents for delaying delivery and improving neonatal and maternal outcomes are prostaglandin inhibitors and calcium channel blockers, according to a meta-analysis published online Oct. 9 in BMJ.

David M. Haas, M.D., from the Indiana University School of Medicine in Indianapolis, and colleagues conducted a systematic review and network meta-analysis to assess the most effective tocolytic agent for delaying delivery.

Of 3,263 titles identified, 95 randomized controlled trials were reviewed. The researchers found that the probability of delivery being delayed by 48 hours was highest with prostaglandin inhibitors (odds ratio [OR], 5.39), followed by magnesium sulfate (OR, 2.76); calcium channel blockers (OR, 2.71); beta mimetics (OR, 2.41); and atosiban, the oxytocin receptor blocker (OR, 2.02), compared with placebo. Side effects necessitating a change of medication were significantly higher for beta mimetics (OR, 22.68), magnesium sulfate (OR, 8.15), and calcium channel blockers (OR, 3.80), compared with placebo. For the outcomes of 48-hour delay in delivery, respiratory distress syndrome, neonatal mortality, and maternal side effects, the tocolytics with the best probability of being ranked in the top three medication classes were prostaglandin inhibitors and calcium channel blockers.

"In this network meta-analysis, prostaglandin inhibitors and calcium channel blockers had the highest probability of delaying delivery and improving neonatal outcomes," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Full Text
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

Featured Jobs



Benefits of Membership

FREE E-Newsletters
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues

CESaver
Join our CESaver program to earn up to 100 contact hours for only $34.95
Register Now

Lippincott's NursingCenter.com
Explore a world of online resources

Become a Member