PCI Linked to Increased Platelet Reactivity

Increase observed after percutaneous coronary intervention despite antiplatelet therapy

FRIDAY, Oct. 12 (HealthDay News) -- Patients with coronary artery disease who receive percutaneous coronary intervention (PCI) have increased platelet reactivity after the procedure despite antiplatelet therapy, according to a study published online Oct. 5 in the Journal of Thrombosis and Haemostasis.

Fabio Mangiacapra, M.D., from OLV Hospital in Aalst, Belgium, and colleagues examined the association between PCI and platelet reactivity in 65 patients with suspected or established stable coronary artery disease taking aspirin and clopidogrel. Fifteen patients underwent coronary angiography, 40 underwent PCI, and 10 underwent rotational atherectomy plus PCI.

The researchers found that platelet reactivity decreased over time in the coronary angiography group, while platelet reactivity significantly increased immediately post-procedure then decreased to baseline at 24 hours in the PCI groups. Peri-procedural variations in platelet reactivity (platelet reactivity post-procedure versus pre-procedure) decreased in the coronary angiography group but significantly increased in both PCI groups. This was associated with total inflation time, total stent length, and E-selectin.

"Despite dual antiplatelet therapy, PCI affected platelet function proportionally to procedural complexity and extent of vascular damage," Mangiacapra and colleagues conclude.

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