View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, Oct. 12 (HealthDay News) -- Patients with coronary artery disease who receive percutaneous coronary intervention (PCI) have increased platelet reactivity after the procedure despite antiplatelet therapy, according to a study published online Oct. 5 in the Journal of Thrombosis and Haemostasis.
Fabio Mangiacapra, M.D., from OLV Hospital in Aalst, Belgium, and colleagues examined the association between PCI and platelet reactivity in 65 patients with suspected or established stable coronary artery disease taking aspirin and clopidogrel. Fifteen patients underwent coronary angiography, 40 underwent PCI, and 10 underwent rotational atherectomy plus PCI.
The researchers found that platelet reactivity decreased over time in the coronary angiography group, while platelet reactivity significantly increased immediately post-procedure then decreased to baseline at 24 hours in the PCI groups. Peri-procedural variations in platelet reactivity (platelet reactivity post-procedure versus pre-procedure) decreased in the coronary angiography group but significantly increased in both PCI groups. This was associated with total inflation time, total stent length, and E-selectin.
"Despite dual antiplatelet therapy, PCI affected platelet function proportionally to procedural complexity and extent of vascular damage," Mangiacapra and colleagues conclude.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top