New Autoinflammatory Disease Linked to NOD2 Mutations ID'd

Common clinical features include inflammatory polyarthritis/polyarthralgia, dermatitis, weight loss

FRIDAY, Nov. 2 (HealthDay News) -- A new autoinflammatory disease characterized by features including inflammatory polyarthritis/polyarthralgia and dermatitis, and involving mutations in the nucleotide-binding oligomerization domain 2 (NOD2) gene has been identified, according to research published online Oct. 26 in the Journal of the American Academy of Dermatology.

Qingping Yao, M.D., Ph.D., of the Cleveland Clinic, and associates prospectively sought to characterize a new category of autoinflammatory disease in 22 non-Jewish, white patients (13 females, nine males; median age at diagnosis, 40.1 years), all of whom had autoinflammatory phenotypes and NOD2 gene mutations.

The patients, who were studied between January 2009 and February 2012, had a mean disease duration of 4.7 years and included three females who were siblings. The researchers identified inflammatory polyarthritis/polyarthralgia (20/22), dermatitis (19/22), weight loss (13/22), and episodic self-limiting fever (13/22) as common clinical features. In 13 patients, gastrointestinal symptoms occurred; sicca-like symptoms were identified in nine patients; and recurrent chest pain was seen in five patients. All patients had mutations in the NOD2 gene, with two variants identified.

"The characteristic clinical phenotype, notably dermatitis, coupled with certain NOD2 variants constitutes a new autoinflammatory disease entity, which we have named as NOD2-associated autoinflammatory disease," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Dogs as Pets, Visitors, Therapists and Assistants
Home Healthcare Nurse, November/December 2014
Free access will expire on January 5, 2015.


Tracheostomy Care
Nursing2014 Critical Care, November 2014
Free access will expire on December 22, 2014.


Effective management of ARDS
The Nurse Practitioner, 13December 2014
Free access will expire on December 22, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events