Whole-Genome Sequencing Helps ID MRSA Outbreaks

Sequencing confirmed outbreak and MRSA carriage in case study from special care baby unit

WEDNESDAY, Nov. 14 (HealthDay News) -- Whole-genome sequencing is promising for rapid, accurate, and comprehensive identification of methicillin-resistant Staphylococcus aureus (MRSA) outbreaks, according to research published online Nov. 14 in The Lancet Infectious Diseases.

Simon R. Harris, Ph.D., from the Wellcome Trust Sanger Institute in Cambridge, U.K., and colleagues assessed the use of whole-genome sequencing to enhance MRSA detection by studying a putative MRSA outbreak on a special care baby unit (SCBU) at a National Health Service Foundation Trust in Cambridge. Findings from an infection-control team through conventional analysis of data were validated and expanded. Isolates from all colonized patients in the SCBU, and MRSA isolates from patients in the hospital or community with the same antibiotic susceptibility profile, were sequenced.

In a six-month period in 2011, the hospital infection-control team identified 12 infants colonized with MRSA, but could not confirm a persistent outbreak. The researchers identified 26 related cases of MRSA carriage using whole-genome sequencing, and demonstrated transmission within the SCBU, between postnatal mothers, and within the community. The MRSA type from the outbreak was identified as a new sequence type (ST) 2371, closely related to ST22. Based on sequencing data, it was confirmed that MRSA carriage by a staff member had allowed the outbreak to persist during periods without known infection on the SCBU and after a deep clean.

"Whole-genome sequencing of MRSA could make an important contribution to infection-control investigation and practice," the authors write. "Such an approach holds great promise for rapid, accurate, and comprehensive identification of bacterial transmission pathways in hospital and community settings, with concomitant reductions in infections, morbidity, and costs."

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events