Head Injury and Paraquat Exposure Up Parkinson's Risk

Exposure to both traumatic brain injury and paraquat linked to three-fold higher risk

FRIDAY, Nov. 16 (HealthDay News) -- The risk of developing Parkinson's disease (PD) is higher for those with a traumatic brain injury (TBI) or exposure to the pesticide paraquat, and is three times higher for individuals with both TBI and paraquat exposure, according to a study published in the Nov. 13 issue of Neurology.

Noting that the combination of TBI with subthreshold paraquat exposure has been suggested to increase dopaminergic neurodegeneration in animals, Pei-Chen Lee, Ph.D., of the University of California at Los Angeles, and colleagues conducted a study involving 357 incident idiopathic PD cases and 754 population controls from central California to examine PD risk due to TBI and paraquat exposure.

The researchers found that subjects who reported TBI had a two-fold increase in the risk of PD (adjusted odds ratio [aOR], 2.00). There was a weaker association observed for paraquat exposure (aOR, 1.36). Participants exposed to both TBI and paraquat had a three-fold increased risk of developing PD compared with those exposed to neither risk factor (aOR, 3.01).

"While TBI and paraquat exposure each increase the risk of PD moderately, exposure to both factors almost tripled PD risk," the authors write. "These environmental factors seem to act together to increase PD risk in a more than additive manner."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events