Decreased Renal Function Linked to Cognitive Decline

Change in renal function tied to changes in global cognition, verbal memory, abstract reasoning

MONDAY, Nov. 19 (HealthDay News) -- Decreased estimated glomerular filtration rates (eGFR) correlate with cognitive decline, according to a study published online Nov. 19 in Nephrology Dialysis Transplantation.

Adam Davey, Ph.D., of Temple University in Philadelphia, and colleagues conducted a five-year longitudinal study involving 590 community-dwelling individuals (mean age, 62.1 years; 60.2 percent female) free from dementia, acute stroke, and end-stage renal disease to examine the change in cognitive functioning over time and its correlation with eGFR.

The researchers found that, after adjustment for eGFR and cognitive function scores at baseline, decreases in eGFR values correlated with cognitive decline. The changes observed in global cognitive ability, verbal episodic memory, and abstract reasoning were significantly linked to change in renal functioning over time. Decreased cognitive functioning in association with a reduction in renal function was noted even after adjustment for demographic variables and cardiovascular disease risk factors as well as exclusion of those individuals with dementia or a history of acute stroke.

"Early detection of mild-to-moderate kidney disease is an important public health concern with regard to cognitive decline," the authors write.

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