Topical Simvastatin Accelerates Wound Healing in Diabetes

Acceleration is due to direct effect on lymphatics and indirect effects via macrophages

MONDAY, Dec. 3 (HealthDay News) -- Topically applied simvastatin accelerates wound healing by directly influencing lymphatics and indirectly via recruitment of macrophages, according to a study published in the December issue of The American Journal of Pathology.

To examine the effect of topically applied statins on wound healing, Jun Asai, M.D., Ph.D., from the Kyoto Prefectural University of Medicine in Japan, and colleagues generated a full-thickness skin wound on the back of diabetic mice and administered simvastatin or vehicle topically.

The researchers found that treatment with topical simvastatin resulted in significant acceleration of wound recovery, with increases noted in both angiogenesis and lymphangiogenesis. Infiltration of macrophages was also promoted by simvastatin, which produced vascular endothelial growth factor C in granulation tissues. Simvastatin directly promoted capillary morphogenesis in vitro, and in lymphatic endothelial cells, simvastatin exerted an antiapoptotic effect.

"The findings of the present study suggest that topical simvastatin can stimulate lymphangiogenesis directly and indirectly via stimulation of macrophages. Vascular remodeling induced by simvastatin might have therapeutic potential in patients with microvascular dysfunction," the authors write. "A future investigation is warranted to determine the potential clinical utility of this approach."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events