View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Dec. 17 (HealthDay News) -- A high-fat meal increases the postprandial glucose levels and insulin requirements of patients with type 1 diabetes, according to research published online Nov. 27 in Diabetes Care.
Howard A. Wolpert, M.D., of the Joslin Diabetes Center in Boston, and colleagues conducted a crossover study that compared glucose control during two 18-hour periods after either a high-fat dinner (60 g) or a low-fat dinner (10 g) with identical carbohydrate and protein content. The protocol was completed by seven patients with type 1 diabetes.
Although considerable interindividual differences were noted, the researchers found that significantly more insulin units were required after a high-fat rather than low-fat dinner (12.6 ± 1.9 units versus 9.0 ± 1.3 units). However, even with additional insulin units, the high-fat meal caused more hyperglycemia. For a high-fat dinner, the carbohydrate-to-insulin ratio was significantly lower.
"The evidence from this study that dietary fat can cause postprandial hyperglycemia in some individuals with type 1 diabetes highlights the limitations of the current carbohydrate-based approach to bolus dose calculation that is widely used in intensive diabetes management," the authors write. "Further studies are needed to develop and validate alternative insulin dosing algorithms for higher-fat meals, and to define new nutritional approaches for minimizing hyperglycemia induced by dietary fat."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top