Teduglutide Seems Effective, Safe for Short Bowel Syndrome

Leads to a significant reduction in parenteral support compared with placebo

WEDNESDAY, Dec. 12 (HealthDay News) -- For patients with short bowel syndrome with intestinal failure (SBS-IF), the glucagon-like peptide 2 analogue teduglutide appears to be safe and reduces the number of days off parenteral support, according to a phase 3 study published in the December issue of Gastroenterology.

Palle B. Jeppesen, M.D., from Rigshospitalet in Copenhagen, Denmark, and colleagues conducted a 24-week study involving patients with SBS-IF who were given once-daily subcutaneous teduglutide (0.05 mg/kg/day; 43 patients) or placebo (43 patients). If 48-hour urine volumes exceeded baseline values by 10 percent or more, parenteral support was reduced.

The researchers found that at weeks 20 and 24 there were significantly more patients with >20 percent reduction in parenteral support volume from baseline among those in the teduglutide group (63 percent) compared with the placebo group (30 percent). The mean reduction in parenteral support volume at 24 weeks was 4.4 ± 3.8 L/week and 2.3 ± 2.7 L/week in the teduglutide and placebo groups, respectively. There was a significantly greater percentage of patients in the teduglutide group with a one-day or more reduction in the weekly need for parenteral support (54 percent) compared to the placebo group (23 percent). Plasma concentrations of citrulline, a biomarker of mucosal mass, increased with teduglutide. Treatment-emergent adverse events were similar between the two groups (two in the teduglutide group and three in the placebo group).

"Twenty-four weeks of teduglutide treatment was generally well tolerated in patients with SBS-IF," the authors write. "Treatment with teduglutide reduced volumes and numbers of days of parenteral support for patients with SBS-IF."

Several authors disclosed financial ties to NPS Pharmaceuticals and Nycomed, both of which funded the study.

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events