Low Insulin Secretion Tied to Depressive Symptoms in Women

Risk of new-onset depressive symptoms up for middle-aged women with lowest insulin secretion

FRIDAY, Dec. 28 (HealthDay News) -- Middle-aged women with insulin secretion levels in the lowest quintile appear to have more than twice the risk of developing new-onset depressive symptoms compared with those with higher insulin secretion levels, according to research published online Dec. 10 in Diabetes Care.

Tasnime N. Akbaraly, Ph.D., of University College London, and colleagues conducted a prospective cohort study involving 3,145 adults (23.5 percent women) with an average age of 60.6 years to examine the correlation between glycemia, insulin resistance, and insulin secretion with subsequent new-onset depressive symptoms.

The researchers found that depressive symptoms developed in 142 men and 84 women over the five-year follow-up. The odds of developing new onset depressive symptoms were 2.18-fold higher for women in the lowest quintile of insulin secretion, defined as the homeostasis model assessment of β-cell insulin secretion ≤55.3 percent, compared with those with higher insulin secretion. Inflammatory markers, cortisol secretion, or menopausal status and hormone replacement therapy did not explain the association. There was no correlation between fasting insulin measures and new-onset depressive symptoms for men, and in neither sex were fasting glucose measures associated with new-onset symptoms.

"Low insulin secretion appears to be a risk factor for new onset depressive symptoms in middle-aged women, although further work is required to confirm this finding," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events