Early Menopause Tied to Greater Type 2 Diabetes Risk

BMI, waist circumference, and smoking do not significantly alter the association

THURSDAY, Dec. 27 (HealthDay News) -- Women who experience early menopause have a greater risk of type 2 diabetes, according to a study published online Dec. 10 in Diabetes Care.

Judith S. Brand, from the University Medical Center Utrecht in the Netherlands, and colleagues analyzed data from 3,691 postmenopausal case subjects with type 2 diabetes and 4,408 subcohort members included in the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition study.

The researchers found that, over a median follow-up of 11 years, relative to women with menopause at age 50 to 54 years, for women with menopause at ages younger than 40; 40 to 44; 45 to 49; and 55 years and older, the hazard ratios (HRs) for type 2 diabetes were 1.32 (95 percent confidence interval [CI], 1.04 to 1.69); 1.09 (95 percent CI, 0.90 to 1.31); 0.97 (95 percent CI, 0.86 to 1.10); and 0.85 (95 percent CI, 0.70 to 1.03), respectively. There was a higher diabetes risk with shorter reproductive life span (HR per SD lower reproductive life span, 1.06; 95 percent CI, 1.01 to 1.12). The effect was not significantly modified by body mass index, waist circumference, or smoking.

"Early menopause is associated with a greater risk of type 2 diabetes," Brand and colleagues conclude.

One author disclosed receiving funding from Novo Nordisk.

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