Urine Biomarkers May Help Diagnose Kawasaki Disease

Filamin C and meprin A elevated in serum and urine of patients with Kawasaki disease

FRIDAY, Dec. 28 (HealthDay News) -- Proteins present in urine exhibit excellent diagnostic performance for Kawasaki disease, according to a study published online Dec. 20 in EMBO Molecular Medicine.

Alex Kentsis, M.D., Ph.D., from Harvard Medical School in Boston, and colleagues used high-accuracy mass spectrometry proteomics to analyze proteins present in the urine of six patients with Kawasaki disease, six patients without Kawasaki disease, and three patients with Kawasaki disease who had completely responded to treatment.

The researchers identified 2,131 unique proteins. Of these, more than 190 were unique to patients with untreated Kawasaki disease and included markers of endothelial and myocardial cell injury and immune regulators. In particular, filamin C and meprin A were significantly elevated in both serum and urine of 236 patients with Kawasaki disease from two independent cohorts. In 107 patients with suspected Kawasaki disease, these two markers were able to diagnose the disease more accurately than current markers, with receiver operating characteristic areas under the curve of 0.98. In a mouse model of Kawasaki disease, meprin A was enriched in the coronary artery lesions.

"In all, urine proteome profiles revealed novel candidate molecular markers of Kawasaki disease, including filamin C and meprin A, that exhibit excellent diagnostic performance," Kentsis and colleagues conclude. "These disease markers may improve the diagnostic accuracy of clinical evaluations of children with suspected Kawasaki disease, lead to the identification of novel therapeutic targets, and allow the development of a biologic classification of Kawasaki disease."

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Meeting the Needs of Family Members of ICU Patients
Critical Care Nursing Quarterly, October/December 2014
Free access will expire on December 22, 2014.


Dealing with the specter of phantom limb pain
Nursing2014 , November 2014
Free access will expire on December 8, 2014.


The Power of Nursing Peer Review
JONA: Journal of Nursing Administration, November 2014
Free access will expire on December 8, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events