Fetuin-A Levels Linked to Cardiovascular Disease Risk

Link between high fetuin-A and lower cardio risk modified by T2DM, obesity, insulin resistance

TUESDAY, Jan. 8 (HealthDay News) -- In elderly individuals without type 2 diabetes, high levels of fetuin-A, a protein that inhibits arterial calcification and insulin action, is associated with a lower risk of cardiovascular disease, according to a study published online Dec. 18 in Diabetes Care.

Majken K. Jensen, Ph.D., from the Harvard School of Public Health in Boston, and colleagues measured serum fetuin-A levels in 1992 in 3,810 individuals 65 years and older (511 with type 2 diabetes) who were free of cardiovascular disease. Participants were followed though June 2008 for incident cardiovascular disease.

During a median follow-up of 10.9 years, the researchers recorded a cardiovascular event in 1,456 individuals overall and in 248 of the individuals with type 2 diabetes. Higher fetuin-A levels were associated with a significantly lower risk of cardiovascular disease in the absence of type 2 diabetes (hazard ratio [HR], 0.93 per 0.1 g/L higher fetuin-A). For individuals with type 2 diabetes, higher fetuin-A levels were associated with a non-significant increase in cardiovascular disease risk. Higher fetuin-A levels were associated with a significantly lower risk of cardiovascular disease only in non-obese individuals (HR, 0.91) and in those with Homeostasis Model Assessment for Insulin Resistance below the median (HR, 0.87).

"In a population of older community-living persons, the association of fetuin-A concentrations with risk of incident cardiovascular disease is modified by insulin resistance and type 2 diabetes," Jensen and colleagues conclude.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events