Vitamin D metabolite levels not tied to coronary artery calcium; carotid intima-media thickness
FRIDAY, April 12 (HealthDay News) -- For individuals with type 1 diabetes, low concentrations of vitamin D metabolites are not associated with an increased risk of subclinical atherosclerosis, according to a study published online March 25 in Diabetes Care.
Michael C. Sachs, Ph.D., from the University of Washington in Seattle, and colleagues examined the association between the levels of circulating vitamin D metabolites (25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D) and subclinical atherosclerosis (coronary artery calcium and common and internal carotid intima-media thickness) in 1,193 patients with type 1 diabetes.
After a median of ten years, the researchers found that lower concentrations of vitamin D metabolites were associated with a lower prevalence and severity of coronary artery calcium. For example, the odds ratio was 0.80 for each 25 nmol/L decrease in 25-hydroxyvitamin D in a fully adjusted model. There was no association between vitamin D metabolite concentrations and common or internal carotid intima-media thickness.
"We did not find evidence linking impaired vitamin D metabolism with increased subclinical atherosclerosis in type 1 diabetes," Sachs and colleagues conclude.
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