Given newborn's vulnerability to pertussis, Tdap vaccine recommended during each pregnancy
TUESDAY, May 28 (HealthDay News) -- The American College of Obstetricians and Gynecologists (ACOG) has endorsed the U.S. Centers for Disease Control and Prevention's updated guidelines for the administration of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) during pregnancy, according to a Committee Opinion published in the June issue of Obstetrics & Gynecology.
The ACOG Committee on Obstetric Practice has updated their guidelines for Tdap immunization during pregnancy. The guidelines are based on the imperative to minimize the burden of pertussis disease in vulnerable newborns, the safety of Tdap in adults, and data relating to the waning of immunity after immunization.
The authors recommend that a dose of Tdap be administered during each pregnancy, regardless of the patient's previous history of receiving Tdap. Although Tdap may be administered at any time during pregnancy, the optimal timing for administration is between 27 and 36 weeks of gestation in order to maximize the maternal antibody response and passive antibody transfer to the newborn. Vaccinating pregnant women with an inactivated virus or bacterial vaccines or toxoids produces no adverse fetal effects, and a growing body of robust evidence demonstrates its safety. For previously unvaccinated women who did not receive Tdap during pregnancy, Tdap should be administered to the mother immediately postpartum in order to reduce the risk of transmission to the newborn. As previously recommended, other family members and prospective direct caregivers should also receive Tdap.
"Given the rapid evolution of data surrounding this topic, immunization guidelines are likely to change over time and the American College of Obstetricians and Gynecologists will continue to issue updates accordingly," the authors write.
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