Link not modified by vitamin D intake; no link observed with vitamin D or calcium intake in men
THURSDAY, May 30 (HealthDay News) -- Women taking up to 1,000 mg/day of calcium supplements and with increased consumption of dietary calcium may have a reduced risk of mortality, according to a study published online May 23 in the Journal of Clinical Endocrinology & Metabolism.
To examine the correlation between calcium and vitamin D intake and mortality, Lisa Langsetmo, Ph.D., from McGill University in Montreal, and colleagues analyzed data from 9,033 randomly-selected, community-dwelling adults participating in the longitudinal Canadian Multicentre Osteoporosis Study who were followed from 1995 to 2007. Total calcium intake was assessed through consumption of dairy, non-dairy food, and supplements; and total vitamin D was assessed through intake of milk, yogurt, and supplements.
The researchers found that over the study period there were 1,160 deaths. No definitive associations were observed for calcium and vitamin D intake and mortality in men. For women, however, there was a possible benefit observed with higher total calcium intake. For every 500-mg increase in daily calcium intake the hazard ratio was 0.95 (95 percent confidence interval, 0.89 to 1.01), with no indication of heterogeneity by source. The use of calcium supplements in women was associated with significantly reduced mortality (hazard ratio, 0.78) for users versus non-users, with significant reductions persisting with doses up to 1,000 mg/day. Concurrent vitamin D intake did not alter these associations.
"Calcium supplements, up to 1,000 mg/day, and increased dietary intake of calcium may be associated with reduced risk of mortality in women," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
Abstract
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