July 2010 
Volume 40  Number 7
Pages 13 - 13
  PDF Version Available!

A study examining the association between suicide risk and antiepileptics has found that certain drugs increase a patient's risk of suicide, attempted suicide, or violent death.An analysis of 297,620 new episodes of antiepileptic treatment identified 26 completed suicides, 801 attempted suicides, and 41 violent deaths. Compared with topiramate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, and valproate were associated with a higher risk of suicidal acts. Compared with carbamazepine, gabapentin was linked to an increased risk in subgroups of younger and older patients, patients with mood disorders, and patients with epilepsy or seizure.Source: Patorno E, Bohn RL, Wahl PM, et al. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA. 2010;303(10):1401–1409.Sipuleucel-T (Provenge), a new autologous cellular immunotherapy, has been approved for the treatment of asymptomatic or minimally symptomatic hormone-resistant metastatic prostate

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