Research Highlights
Jennifer M. Salsberg

Journal of the Dermatology Nurses' Association
June 2011 
Volume 3  Number 3
Pages 168 - 169
  PDF Version Available!

Yang, Y. W., Chin-Shyan, C., Yi-Hua, C., & Herng-Ching, L. (2011). Psoriasis and pregnancy outcomes: A nationwide population-based study. Journal of the American Academy of Dermatology, 64(1), 71-77.Psoriasis is a chronic inflammatory skin condition involving T-helper type 1 cell up-regulation and release of inflammatory cytokines. Previous studies on pregnancy outcomes in women with other chronic inflammatory conditions such as inflammatory bowel disease or rheumatoid arthritis have shown an increased risk of low birth weight, small-for-gestational-age babies, and increased rates of cesarean section. Although other inflammatory conditions are associated with adverse outcomes in pregnancy, there is limited data regarding pregnancy outcomes in women with psoriasis. The goal of this study was to determine whether there is an association between psoriasis and adverse pregnancy outcomes.Authors of this study analyzed the data from two nationwide population-based data sets. One thousand four hundred and sixty-three women with a principal diagnosis of psoriasis made in the previous 2 years by a dermatologist and with a singleton live birth within the 3-year study period were included as cases in the study. These patients were further subdivided into severe psoriasis (patients who had received photochemotherapy or systemic therapy within 2 years prior to the study) or mild psoriasis. A random selection of 11,704 women who delivered babies during that time period without a diagnosis of psoriasis served as controls. Results of the study showed no difference in the amount of low-birth-weight, preterm, or small-for-gestational-age babies and no increased risk of cesarean section, preeclampsia, or eclampsia between the mild psoriasis and control groups. For mothers with severe psoriasis, there was no significant increase in preterm birth, cesarean section, small-for-gestational-age babies, preeclampsia, and eclampsia. However, patients in the severe psoriasis group were found to

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