DRUG CHALLENGE: Drugs for treating Parkinson disease
Jennifer Belavic PharmD

July 2012 
Volume 42  Number 7
Pages 69 - 69
  PDF Version Available!

Do you know what they contain? Match the brand names in Section I with the generics in Section II._____ 1. Sinemet (Merck)_____ 2. Apokyn (Tercica)_____ 3. Comtan (Novartis)_____ 4. Azilect (Teva Neuroscience)This dopamine agonist works by mimicking dopamine effects in the brain. It can be used in combination with levodopa to smooth its wearing-off effect. It's the only injectable dopamine agonist. Adverse reactions include hallucinations, edema, lethargy, and dyskinesias.A catechol-O-methyltransferase inhibitor, this drug helps increase levodopa's effects by blocking the enzyme that breaks down levodopa. Adverse reactions include dyskinesias and orthostatic hypotension.This combination drug allows levodopa to pass into the brain before it undergoes premature conversion to dopamine. After long-term use, levodopa's benefit may decrease and the patient can experience a wearing-off effect. Adverse reactions include nausea, orthostatic hypotension, and dyskinesias with higher doses.A monoamine

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