November 2012 
Volume 42  Number 11
Pages 8 - 9
  PDF Version Available!

Researchers conducted an analysis of 293,094 outpatients on chronic hemodialysis to determine which antibiotics may reduce morbidity and mortality associated with Staphylococcus aureus. Among the study population, the rate of bacteremia was 15.4 per 100 outpatient-years. The incidence rate for methicillin-sensitive Staphylococcus aureus (MSSA) was 2.1 per 100 patient-years, and the rate for methicillin-resistant Staphylococcus aureus was 1.9 per 100 patient-years.One week after the index blood culture was collected, 56.1% of outpatients with MSSA bacteremia were receiving vancomycin and 16.7% were receiving cefazolin. Cefazolin was associated with a 38% lower risk for hospitalization or death compared with the adjusted rate for vancomycin. Researchers concluded that the risk of treatment failure may be higher in patients treated with vancomycin than in those treated with a B-lactam antibiotic such as cefazolin.Source: Chan KE, Warren HS, Thadhani RI, et al. Prevalence and outcomes of antimicrobial treatment for staphylococcus aureus bacteremia in outpatients with ESRD. J Am Soc Nephrol. 2012;23(9):1551-1559.Ivermectin lotion 0.5% is a pediculicide now available for the topical treatment of head lice in patients age 6 months and older. In phase 3 trials, ivermectin lotion was proven to resolve most head lice infestations after one 10-minute application. Two weeks after this initial treatment, 71% to 76% of patients were lice-free.A small percentage of patients (less than 1%) experienced adverse reactions, which included conjunctivitis, ocular hyperemia, eye irritation, dandruff, dry skin, and burning sensation of the skin. Ivermectin lotion is indicated for topical use on the hair and scalp and is available by prescription only.Source: Sklice(R) (ivermectin) lotion, 0.5% now available in the U.S. for topical treatment of head lice. [Press Release.] 2012. http://www.prnewswire.com/news-releases/sklice-ivermectin-lotion-05-now-available-in-the-us-for-topical-treatment-of-head-lice-166784966.html

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