DRUG NEWS: Obesity, diabetes linked to drug therapy

April 2004 
Volume 34  Number 4
Pages 10 - 10
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    Health care professionals should carefully monitor people who take certain antipsychotic drugs for development of diabetes, obesity, and dyslipidemia. Participating in a consensus conference, experts from four organizations, including the American Diabetes Association (ADA), evaluated recent studies that link second-generation antipsychotic drugs with metabolic disorders. They found that clozapine (Clozaril) and olanzapine (Zyprexa) are more closely associated with weight gain, diabetes, and dyslipidemia than risperidone (Risperdal) or quetiapine (Seroquel). Aripiprozole (Abilify) and ziprasidone (Geodon) weren't associated with these disorders, but they haven't been as widely used as other drugs in this category.

    The experts ask health care professionals to screen for obesity, diabetes, dyslipidemia, and high blood pressure before prescribing an antipsychotic drug and to closely monitor the patient's response to treatment. ...

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