DRUG NEWS: Erythromycin linked to cardiac arrest

December 2004 
Volume 34  Number 12
Pages 30 - 30
  PDF Version Available!


  • Source

    Taking the familiar antibiotic erythromycin with certain other drugs that raise its concentration in the blood increases the risk of sudden cardiac arrest five times, according to a recent study involving 1,476 cases of confirmed sudden cardiac death. Taken alone, erythromycin doubled the low risk of sudden cardiac death.

    At high blood concentrations, erythromycin can prolong cardiac repolarization, potentially triggering a fatal arrhythmia. Drugs that inhibit the cytochrome P450 3A (CYP 3A) metabolic pathway, such as nitroimidazole antifungal drugs, diltiazem, verapamil, and troleandomycin, interact with erythromycin this way.

    Studying the medical records of Medicaid patients from Tennessee who died of cardiac arrest between 1988 and 1993, researchers looked for people who'd taken erythromycin or amoxicillin (which doesn't prolong cardiac repolarization). They also checked for concurrent use of drugs that greatly inhibit ...

Purchase Now !

To purchase this item, follow the instructions below. If you’re not already logged in, be sure to enter your login information below to ensure that your item is saved to your File Drawer after you purchase it.

Not a member? Join now for Free!

1) If you're not already logged in, enter your information below to save this item in your File Drawer for future viewing.

User name:


Forgot your user name or password?
2)  If you have a coupon or promotional code, enter it
here.(If not, just click Continue.

Digital Coupon: (optional)

3)  Click Continue to go to the next screen, where
you'll enter your payment details.

Featured Jobs

Benefits of Membership

FREE E-Newsletters
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues

Join our CESaver program to earn up to 100 contact hours for only $34.95
Register Now

Lippincott's NursingCenter.com
Explore a world of online resources

Become a Member