View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
Drugs that reduce gastric acid secretion can increase a person's risk of pneumonia, according to results of a study involving more than 300,000 people. People taking proton pump inhibitors such as esomeprazole (Nexium), lansoprazole (Prevacid), and omeprazole (Prilosec) had almost twice the risk of developing community-acquired pneumonia as former users of these drugs.
Proton pump inhibitors are commonly prescribed to treat heartburn and other symptoms associated with gastroesophageal reflux disease. Researchers theorize that by reducing germ-killing stomach acid, these drugs allow pathogens from the upper gastrointestinal tract to colonize the respiratory tract.
Researchers reviewed the medical records of 364,683 patients and identified 5,551 cases of pneumonia. They found that 185 of these infections occurred in people taking acid-suppressing drugs. Researchers say their findings translate to about one case of pneumonia for every 226 patients taking proton pump inhibitors. Histamine2-receptor antagonists, such as cimetidine (Tagamet) and famotidine (Pepcid), also raised the risk of pneumonia, but not as much: For patients taking these drugs, the findings translate to about one case of pneumonia for every 508 patients.
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs, JAMA, RJ Laheij, et al., October 27, 2004.
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top