DRUG NEWS: Gender gap found for aspirin therapy

May 2005 
Volume 35  Number 5
Pages 30 - 30
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  • Compared with men, women may get less benefit from aspirin prescribed to prevent myocardial infarction (MI)—but significantly more protection from stroke.

    In the first large clinical trial designed to test aspirin's cardiovascular benefits for women, researchers found that healthy women taking low-dose aspirin (100 mg on alternate days) were no less likely to have a first MI than women taking a placebo. But the stroke rate was 17% lower overall among women taking aspirin, and 24% lower for ischemic stroke, the most common type. Although aspirin has been shown to lower the risk of a first MI in men, it hasn't conclusively been shown to lower stroke risk in men.

    Researchers, who were surprised by this gender gap, say their findings are especially significant because many more women in the study had strokes than MIs.

    The study involved 39,876 women (half taking aspirin on alternate days and half taking ...

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