DRUG NEWS: Aspirin safer than warfarin and just as effective

June 2005 
Volume 35  Number 6
Pages 30 - 30
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    New research shows that aspirin is safer than warfarin and just as effective at preventing stroke and vascular death in patients with symptomatic stenosis of a major intracranial artery. Researchers stopped the study early due to concerns for the safety of patients taking warfarin.

    The study involved 569 patients with symptomatic intracranial arterial stenosis. All patients had a greater than 50% stenosis of a major intracranial artery. They'd also all had a transient ischemic attack or nondisabling stroke within 90 days of enrolling in the study.

    Researchers randomly assigned patients to receive either warfarin (target international normalized ratio [INR], 2 to 3) or 1,300 mg of aspirin daily. During an average follow-up period of 1.8 years, the rate of death, major hemorrhage, myocardial infarction, and sudden death were significantly higher among patients taking warfarin compared with those in the aspirin group. The ...

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