CLINICAL QUERIES: Are NSAIDs safe for arthritis pain?
Cathy Flasar RN, BC, FNP, MSN
Joan D. Wentz RN, MSN

December 2006 
Volume 36  Number 12
Pages 24 - 24
  PDF Version Available!


Flasar, Cathy RN, BC, FNP, MSN; Wentz, Joan D. RN, MSN

Many of my older patients have osteoarthritis. Can they safely use selective or nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) to treat their chronic pain? - —A.D., MD.

Cathy Flasar, RN, BC, FNP, MSN and Joan D. Wentz, RN, MSN, reply: Your concern is understandable. Two selective NSAIDs, the cyclooxygenase-2 (COX-2) inhibitors rofecoxib (Vioxx) and valdecoxib (Bextra), were withdrawn from the market because of cardiovascular risks. Celecoxib (Celebrex) is the only COX-2 inhibitor available in the United States. Nonselective NSAIDs such as ibuprofen are available over the counter (OTC); others like diclofenac are available by prescription.

Like the other COX-2 inhibitors, celecoxib has been found to raise cardiovascular risks, but the risk is dose-related. (The higher the dose, the greater the risk.) Ibuprofen and diclofenac appear to carry the lowest cardiovascular risk of all the NSAIDs except aspirin.

Current ...

Purchase Now !

To purchase this item, follow the instructions below. If you’re not already logged in, be sure to enter your login information below to ensure that your item is saved to your File Drawer after you purchase it.

Not a member? Join now for Free!

1) If you're not already logged in, enter your information below to save this item in your File Drawer for future viewing.

User name:


Forgot your user name or password?
2)  If you have a coupon or promotional code, enter it
here.(If not, just click Continue.

Digital Coupon: (optional)

3)  Click Continue to go to the next screen, where
you'll enter your payment details.

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events