View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
Women who develop gestational diabetes mellitus (GDM) have a high risk of developing type 2 diabetes later in life. Treatment with metformin may prevent or delay the development of diabetes in these women, a new study suggests, although intensive lifestyle interventions proved equally effective.
The study included 350 women with a history of GDM and 1,416 women who'd given birth to at least one child and had no history of GDM. They were randomly assigned to receive standard lifestyle intervention and placebo, metformin therapy, or intensive lifestyle intervention. All women had similar glucose levels at the start of the study.
Following the women for 3 years, researchers found that those with a history of GDM on placebo therapy had a 71% increased incidence of diabetes compared with women with no history of GDM. Among women with a history of GDM, both metformin therapy and intensive lifestyle intervention reduced risk by about 50%, compared with the placebo group.
For women who'd never had GDM, metformin therapy decreased the incidence of diabetes by 14%, but intensive lifestyle intervention reduced their risk by 49%.
Researchers concluded that both intensive lifestyle intervention and metformin are "highly effective" in delaying or preventing diabetes in women with impaired glucose tolerance and a history of GDM.
Source: Ratner RE, Christophi CA, Metzger BE, et al. Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. J Clin Endocrinol Metab. 2008;93(12):4774-4779.
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top