Genomics: A paralyzing look at pseudocholinesterase deficiency
Chris A. Wolf RN

$3.95 		OR Nurse 2013
November 2009 
Volume 3  Number 6
Pages 10 - 11
 
  PDF Version Available!

ABSTRACT

Pseudocholinesterase deficiency (PD) is an uncommon genetic disorder that can cause sensitivity to neuromuscular blocking agents in affected persons. When neuromuscular blocking agents such as succinylcholine or mivacurium are administered to susceptible individuals during surgery, the result is prolonged intercostal muscles paralysis, because of the slowed metabolic breakdown of the drug due to this genetic disorder.


Pseudocholinesterase is a glycoprotein enzyme produced by the liver that hydrolyzes choline esters, such as those found in succinylcholine. 2 About 96% of the population carries ...

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