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Fluids & Electrolytes
Although there is currently no standard of care for postlaser resurfacing treatment of the face, postsurgical treatment that speeds reepithelialization, reduces downtime, and increases comfort is desirable. This study compared the wound-healing efficacy and safety of Aquaphor and Biafine after laser resurfacing of the perioral area.
In this double-blind study, 20 participants with perioral rhytides received fractional CO2 laser resurfacing. Aquaphor and Biafine were applied to opposite sides of the face four times daily after treatment. Clinical grading of erythema, edema, epithelial confluence, and crusting or scabbing; subjective irritation; and general wound appearance were assessed (4-point scale) on Days 2, 4, 7, and 14. Participants ranked the two treatment sites daily.
Aquaphor resulted in significantly less erythema (Days 2 and 7) and crusting or scabbing (Days 2, 4, and 7) and higher epithelial confluence (Day 4) than did Biafine (p <= .042). Subjective irritation assessments demonstrated significantly less stinging, itching, and tightness at Day 2 and tightness at Day 7 with Aquaphor than Biafine (p <= .049). General wound appearance was graded significantly higher for Aquaphor on Days 2 and 7 (p <= .049). Significantly more participants preferred Aquaphor to Biafine (p <= .046).
Aquaphor exhibited superiority to Biafine in several wound-healing parameters and in overall wound condition.
Aquaphor Healing Ointment creates a moist wound environment that supports healing and provides a low-cost option for postlaser resurfacing treatment.
Atiyeh, B. S., Dham, R., Costagliola, M., Al-Amm, C. A., & Belhaouari, L. (2004). Moist exposed therapy: An effective and valid alternative to occlusive dressings for postlaser resurfacing wound care. Dermatologic Surgery, 30(1), 18-25.
Cohen, J. L., Jorizzo, J. L., & Kircik, L. H. (2007). Use of a topical emulsion for wound healing. Journal of Supportive Oncology, 5(10 Suppl. 5), 1-9.
Doughty, D. (2005). Dressings and more: Guidelines for topical wound management. Nursing Clinics of North America, 40(2), 217-231.
Gotkin, R. H., Sarnoff, D. S., Cannarozzo, G., Sadick, N. S., & Alexiades-Armenakas, M. (2009). Ablative skin resurfacing with a novel microablative CO2 laser. Journal of Drugs in Dermatology, 8(2), 138-144.
Manstein, D., Herron, G. S., Sink, R. K., Tanner, H., & Anderson, R. R. (2004). Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers in Surgery and Medicine, 34(5), 426-438.
Rendon, M., Cardona, L., & Benitez, A. (2008). The safety and efficacy of trolamine/sodium alginate topical emulsion in postlaser resurfacing wounds. Journal of Drugs in Dermatology, 7(Suppl. 5), s23-s28.
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