ASH: Catheter-Directed Thrombolysis Cuts DVT Risks

CDT lowers post-thrombotic syndrome frequency, ups iliofemoral patency in deep vein thrombosis

TUESDAY, Dec. 13 (HealthDay News) -- For patients with deep vein thrombosis (DVT), additional catheter-directed thrombolysis (CDT) reduces the frequency of post-thrombotic syndrome (PTS) and improves iliofemoral patency, according to a study published online Dec. 13 in The Lancet to coincide with presentation at the annual meeting of the American Society of Hematology, held from Dec. 10 to 13 in San Diego.

Tone Enden, M.D., from the University of Oslo in Norway, and colleagues investigated whether additional treatment with CDT reduced development of PTS. A total of 209 patients, aged 18 to 75 years, with first-time iliofemoral DVT were selected within 21 days from symptom onset. Participants were randomly assigned to conventional treatment alone (108 patients) or additional CDT (101 patients). Co-primary outcomes were the frequency of PTS, as measured by Villalta score at 24 months, and iliofemoral patency after six months, which were assessed by intention-to-treat analysis.

The investigators found that clinical status data were available for 90 percent of patients after completion of 24 months of follow-up. PTS was identified in 41.1 percent of patients given additional CDT, compared with 55.6 percent of patients in the control group at 24 months (P = 0.047), corresponding to an absolute risk reduction of 14.4 percent. Iliofemoral patency after six months was reported in significantly more patients in the CDT group versus controls (65.9 versus 47.4 percent). Three major and five clinically relevant bleeds were identified among 20 bleeding complications related to CDT.

"Additional CDT should be considered in patients with a high proximal DVT and low risk of bleeding," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events